diff --git a/drivers/i2c/busses/i2c-stm32f7.c b/drivers/i2c/busses/i2c-stm32f7.c
index c8ce6c8dd404..073bf57a9821 100644
--- a/drivers/i2c/busses/i2c-stm32f7.c
+++ b/drivers/i2c/busses/i2c-stm32f7.c
@@ -1503,7 +1503,7 @@ static irqreturn_t stm32f7_i2c_isr_error(int irq, void *data)
 	void __iomem *base = i2c_dev->base;
 	struct device *dev = i2c_dev->dev;
 	struct stm32_i2c_dma *dma = i2c_dev->dma;
-	u32 mask, status;
+	u32 status;
 
 	status = readl_relaxed(i2c_dev->base + STM32F7_I2C_ISR);
 
@@ -1528,12 +1528,15 @@ static irqreturn_t stm32f7_i2c_isr_error(int irq, void *data)
 		f7_msg->result = -EINVAL;
 	}
 
-	/* Disable interrupts */
-	if (stm32f7_i2c_is_slave_registered(i2c_dev))
-		mask = STM32F7_I2C_XFER_IRQ_MASK;
-	else
-		mask = STM32F7_I2C_ALL_IRQ_MASK;
-	stm32f7_i2c_disable_irq(i2c_dev, mask);
+	if (!i2c_dev->slave_running) {
+		u32 mask;
+		/* Disable interrupts */
+		if (stm32f7_i2c_is_slave_registered(i2c_dev))
+			mask = STM32F7_I2C_XFER_IRQ_MASK;
+		else
+			mask = STM32F7_I2C_ALL_IRQ_MASK;
+		stm32f7_i2c_disable_irq(i2c_dev, mask);
+	}
 
 	/* Disable dma */
 	if (i2c_dev->use_dma) {