diff --git a/lib/Kconfig.kmsan b/lib/Kconfig.kmsan
index b2489dd6503f..ef2c8f256c57 100644
--- a/lib/Kconfig.kmsan
+++ b/lib/Kconfig.kmsan
@@ -12,6 +12,7 @@ config KMSAN
 	bool "KMSAN: detector of uninitialized values use"
 	depends on HAVE_ARCH_KMSAN && HAVE_KMSAN_COMPILER
 	depends on SLUB && DEBUG_KERNEL && !KASAN && !KCSAN
+	depends on !PREEMPT_RT
 	select STACKDEPOT
 	select STACKDEPOT_ALWAYS_INIT
 	help