diff --git a/reactbot/config.py b/reactbot/config.py
index 379dead..1f37570 100644
--- a/reactbot/config.py
+++ b/reactbot/config.py
@@ -53,6 +53,7 @@ class Config(BaseProxyConfig):
     def _make_rule(self, name: str, rule: Dict[str, Any]) -> Rule:
         try:
             return Rule(rooms=set(rule.get("rooms", [])),
+                        not_rooms=set(rule.get("not_rooms", [])),
                         matches=self._compile_all(rule["matches"]),
                         not_matches=self._compile_all(rule.get("not_matches", [])),
                         type=EventType.find(rule["type"]) if "type" in rule else None,
diff --git a/reactbot/rule.py b/reactbot/rule.py
index 49220c1..441ffb7 100644
--- a/reactbot/rule.py
+++ b/reactbot/rule.py
@@ -31,6 +31,7 @@ RPattern = Union[Pattern, SimplePattern]
 @dataclass
 class Rule:
     rooms: Set[RoomID]
+    not_rooms: Set[RoomID]
     matches: List[RPattern]
     not_matches: List[RPattern]
     template: Template
@@ -46,6 +47,8 @@ class Rule:
     def match(self, evt: MessageEvent) -> Optional[Match]:
         if len(self.rooms) > 0 and evt.room_id not in self.rooms:
             return None
+        elif evt.room_id in self.not_rooms:
+            return None
         for pattern in self.matches:
             match = pattern.search(evt.content.body)
             if match: